Name: Ticarcillin (Ticar)
Class: Penicillin (Extended spectrum)
Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.
Absorption: IM, IV.
Distribution: Widely distributed, little CSF unless meninges inflamed.
Metab.:
Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.
Toxicity/S.E.s: hypersensitivity (1-10%), superinfection., coagulation disorders.
Utility: Gram -. Effective against Pseudomonas, Proteus mirabilus, often used w/aminoglyc.
Special Features: Narrow spectrum. Resistance develops quickly.