Name: Penicillin V
Class: Penicillin (Penicillin G-related)
Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.
Absorption: Acid stable ® good oral absortption.
Distribution: Widely distributed, little CSF unless meninges inflamed.
Metab.:
Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.
Toxicity/S.E.s: : hypersensitivity (1-10%), superinfection.
Utility: Mild to moderate infections only: Many gram +, anaerobes, and a few gram -. Most staph. and gram - resistant. Same spectrum as Pen. G, but less active.
Special Features: Narrow spectrum.