Minocyclin (Minocin) -|- Pharmacology Mnemonics - Flash Cards

Minocyclin (Minocin)

Post a comment

Name: Minocyclin (Minocin)

Class: Tetracycline

Mech.: Active uptake into bacteria ®inhib protein synth by binding to 30S ribosome. Bacteriostatic

Absorption: Good oral absorption. Impaired by divalent cations. IM painful. IV may cause thrombophlebitis. Never intrathecal.

Distribution: Good CSF. Conc. in liver ® enterohepatic circ. Penetrates most tissues and fluids. Also enters tears and saliva. Crosses placenta.

Metab.: Liver, but not critical.

Excretion, t½: bile; doesn’t require renal excretion

Toxicity/S.E.s: Vestibular toxicity; GI — burning, discomfort, nausea, vomitiing; superinfection — due to broad spectrum, candida albicans (1°), staph enterocolitis, pseudomemb. colitis; hepatotoxicity (esp. in pregnancy); renal toxicity; Fanconi synd.; perm. brown discoloration of teeth; slowing of bone growth; phototoxicity; thrombophlebitis; hematopoetic changes; rare hypersens. rxns.

Utility: gram - cocci, gram - bacilli, acid fast bacilli, chlamydiae, mycoplasma, rickettsia, spirochetes. No effect on viruses or fungi. Also used for acne, prophylaxis for Travelers’ diarrhea.

Special Features: Broad spectrum. Decreased effect of oral contraceptives.