Name: Sulfamethoxazole (Gantanol)Class: Sulfonamide
Mech.: Comp. inhib. of PABA incorp. into dihydropteric acid ® inhib. of folic acid. Bacteriostatic.
Absorption: Rapidly absorbed in GI tract (slower than isoxazole). Parenteral.
Distribution: Widely distrib; limited CSF. Crosses placenta.
Metab.: Acetylated in liver
Excretion, t½: Renal filtration, secretion
Toxicity/S.E.s: Hypersensitivity—fever, rash, photosensitivity; UT disturbances— deposition of crystalline aggregates; hematopoetic disorders—dyscrasias
Utility: Uncomplicated UTIs, trachoma (contag. disease of eyelid, conjunct, cornea), nocardiosis (tuberculosis-like infect.), prophylaxis (burnt skin, suppressing recurring UTIs, rheumatic fever)
Special Features: Spectrum—gram +, gram -.