Name: GM-CSF (Sargramostim)
Class: Immunostimulant
Mechanism: Stim. bone marrow production of precursors to PMNs, monocytes, platelets. Also activates PMNs, eosinophils, and monocytes.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Fever, dermatologic rxns, splenomegaly.
Utility: FDA-approved to increase myeloid recovery rate after bone marrow transplantation. Also used for hematological reconstitution after autologous bone marrow transplants and treatments w/bone marrow cytotoxic drugs.
Special Features: Greater severity of immunologic S.E.s than w/G-CSF.