Name: Thyroglobulin (Proloid)
Class: Thyroid Hormone
Mechanism: T3/T4 synergize w/GH effects, increase BMR, potentiate catecholamine effects on heart, promote lipolysis, and decrease serum cholesterol.
Absorption: Oral
Dist.: Poor placental transfer ® okay for pregnant E. Little in milk (use cautiously).
Metabolism.: T4 & T3 released by proteolysis after ingestion. Hepatic conjug. of T4/T3 w/glucuronic & sulfuric acids.
Excretion, t½: Bile; some lost in stool due to enterohepatic circulation.
Toxicity/S.E.s: Salicylates and dicumarol compete for albumin binding sites ® marked increase of free levels.
Utility: Treat hypothyroidism and goiter (not due to iodine deficiency or hyperthyroidism).
Special Features: 120-180 mg/d. Similar efficacy to levothyroxine sodium and liothyronine sodium, although dose not standardized by bioassay