Name: Misoprostol (Cytotec)
Class: Gastric Protectant (Prostaglandin)
Mechanism: Analog of prostaglandin E1. Inhib. secretion of HCl. Stimulates secretion of mucus & HCO3 (cytoprotective).
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Diarrhea, nausea. Produces uterine contractions. \ c/i during pregnancy.
Utility: Only agent approved for prevention of gastric ulcers induced by NSAIDs. Less effective than H2 antagonists for acute treatment of peptic ulcers.
Special Features: