Name: Nitroprusside (Nipride)
Class: Antihypertensive Agent
Mechanism: Stim. membrane-assoc. guanylyl cyclase in vascular smooth muscle cells ® intracellular cGMP ® activation of cGMP-dependent protein ® vasodilation of arterial and venous vessels® reflex tachycardia. Reduces BP in all pts., regardless of etiology. Decreases afterload and preload.
Absorption: Continuous IV infusion. Oral ® cyanide poisoning.
Dist.:
Metabolism.:
Excretion, t½: Minutes
Toxicity/S.E.s: Tachycardia, hypotension, cyanide toxicity (Rx w/sodium thiosulfate).
Utility: Hypertensive emergencies.
Special Features: