Name: Amoxicillin (Amoxil)
Class: Penicillin (Aminopenicillin)
Mechanism: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.
Absorption: Acid stable. Good oral (better than ampicillin).
Distrib.: Widely distributed, little CSF unless meninges inflamed.
Metabolism.:
Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.
Toxicity/S.E.s: diarrhea (less than ampicillin), hypersensitivity (1-10%), superinfection.
Utility: More effective against gram -s (esp. Proteus, H. influenzae, E. coli, P. mirabilis). Less active than Pen. G against gram+ cocci. H. pylori (PUD).
Special Features: Broad spectrum.