Name: Norfloxacin (Noroxin)
Class: Fluorinated quinolone
Mechanism: Inhib bact. DNA gyrase (topoisomerase II). Bactericidal.
Absorption: Oral admin.
Distrib.: Good tissue penetration.
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Usu. not severe. GI, CNS. Not for pregnant or nursing women or prepubertal children.
Utility: UTIs due to Enterobacteriaceae, Enteroccus, Staph, Pseudomonas. Infectious diarrhea.
Special Features: Broader spectrum than nonfluorinated quinolones. For diarrhea, treat until symptoms resolve, or no longer than 3 days.