Name: Docusates (Colace, Doxinate)
Class: Laxative
Mechanism: Anionic surfactant. Becomes emulsified w/stool ® softer feces, easier passage. Requires 1-3 days for action.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: May increase intestinal absorption of other drugs. Don’t use w/lubricant oils. May be mutagenic to cultured liver cells.
Utility: Laxative. Use limited to keeping stool soft.
Special Features: Only a minimal laxative effect at recommended dosage.