Name: Bismuth-Subsalicylate (Pepto-Bismol)
Class: Cytoprotective Agent/Hydrophilic Agent/Absorbent/Antimicrobial.
Mechanism: Inhib. pepsin activity, mucus secretion, coats & protects ulcer. Antimicrobial action. May have antiinflammatory action.
Absorption:
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Excretion, t½:
Toxicity/S.E.s: Binds tetracyclines. Turns stools and tongue black. Contains salicylate ® additive effects w/aspirin, tinnitus. Don’t use w/salicylate allergy. May cause GI impaction in debilitated patients.
Utility: PUD. Traveler’s Diarrhea (at least in Mexico)—8 doses (1-2 tablets every eight hours). Prophylaxis for Traveler’s Diarrhea. General diarrhea (usu. controls diarrhea w/in 24 hr).
Special Features: