Name: Mexiletine (Mexitil)
Class: Antidysrhythmic Agent (Class IB)
Mechanism: Shortens phase 3 repolarization. Decreases action potential duration. Inhibits arrhythmias caused by abnormal automaticity. Rapid speed of dissociation from Na+ channels.
Absorption: Oral
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Proarrhythmic effects, negative inotropy, infranodal conduction block. N/v, dizziness, disorientation, tremor.
Utility: Chronic treatment of ventricular arrhythmias assoc. w/previous myocardial infarction.
Special Features: Concurrent use w/quinidine may be effective at lower doses than either alone ® ¯ adverse effects of each.