Name: Flecainide (Tambocor)
Class: Antidysrhythmic Agent (Class IC)
Mechanism: Slow dissociation from Na+ channels ® marked suppression of phase 0 upstroke ® marked slowing of conduction. threshold potential ® ¯ automaticity.
Absorption: Oral.
Dist.:
Metabolism.: Minimal.
Excretion, t½: 16-20 hr.
Toxicity/S.E.s: Long-term Rx ® mortality. Dizziness, blurred vision, tremor, agitation, headache, nausea. Aggravation of preexisting arrhythmias, negative inotropy, induction of life-threatening ventricular tachycardia (CAST proarrhythmia), aggravation of CHF, infranodal conduction block.
Utility: Treat refractory ventricular arrhythmias. Suppress premature ventricular contraction. Treat AV nodal reentry, WPW-related arrhythmia.
Special Features: Class IC drugs have the highest potency as Na+ channel blockers