Name: Sucralfate (Carafate)
Class: Cytoprotective Agent
Mechanism: Complex of aluminum hydroxide and sulfated sucrose. Forms complex gels w/mucus ® physical barrier than impairs diffusion of HCl and prevents peptic mucus degradation. Stim. prostaglandin release and secretion of mucus and bicarbonate. Inhib. acid secretion by ~50%.
Absorption: Not absorbed.
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Well tolerated.
Utility: PUD
Special Features: Largely supplanted by H2RAs and PPIs. Requires acidic pH for activation. \ should not be admin. w/antacids, PPIs, or H2RAs.