Name: Baclofen (Lioresal)
Class: Muscle Relaxant (Centrally Acting)
Mechanism: GABAB agonist ® inhib. of neurotrans. release ® ¯ release of glutamate from Ia afferents & upper motor neurons.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Sedation (much less than diazepam), seizure activity in epileptics, dizziness, blurred vision, muscle weakness, ataxia.
Utility: Preferred drug for treatment of spasticity assoc. w/ALS, spinal cord trauma, multiple sclerosis, & cerebral palsy.
Special Features: