Name: Prochlorperazine (Compazine)
Class: Antiemetic (Phenothiazine)
Mechanism: Blocks DA receptors in CTZ and GI tract. Probably also depresses vomiting center somewhat.
Absorption: Oral, suppository.
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Drowsiness, hypotension. Hypersens—blood dyscrasias, jaundice, skin rashes. Dystonias, dyskinesias, Parkinsonism (more often
than w/chlorpromazine).
Utility: Antiemetic for drugs, radiation, uremia, pain, post-op, emotional, GI irritation, cancer chemotherapy. Also very effective for intractable hiccoughs.
Special Features: Best if admin. prophylactically.