Name: Entacapone
Class: Antiparkinsonian (COMT Inhibitor)
Mechanism: Inhib. COMT ® plasma conc. of L-Dopa ® free L-Dopa in brain ® DA in brain.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Nausea (from peripheral DA), dyskinesia.
Utility: Treat symptoms of Parkinson’s Disease. Increases duration of response to L-Dopa, decreases required daily dose of L-Dopa.
Special Features: