Name: Ethosuximide (Zarontin)
Class: Antiepileptic Agent (Absence)
Mechanism: Reduces T-channel Ca2+ currents ® seizure threshold.
Absorption:
Dist.: 0% protein binding.
Metabolism.:
Excretion, t½: 20-60 hr (adults & kids)
Toxicity/S.E.s: Dose-related—anorexia, nausea, fatigue, headache. Non-dose-rel.—blood-dyscrasia, SLE-like rxn, hepatitis.
Utility: A DOC for uncomplicated absence.
Special Features: