Name: Promethazine (Phenergan, Remsed)
Class: Antiemetic (H1-Histamine Antagonist) (OTC)
Mechanism: Competitive inhib. of histamine and histamine receptor interaction.
Absorption: Oral, suppository.
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: More drowsiness than other antihistamines. Mild anticholinergic effects.
Utility: Prevent motion sickness. Can be used for morning sickness. Vertigo.
Special Features: May be effective in motion sickness when other antihistamines are not. Best if admin. prophylactically.