Name: Metoclopramide (Reglan)
Class: Antiemetic
Mechanism: Cholinomimetic action ® GI motility. Potent DA antagonism ® blockade of DA receptors in CTZ and GI. Prob. also depresses vomiting center.
Absorption: Oral
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Somnolence, nervousness, dystonic rxns. Some Parkinsonism & tardive dyskinesia. Some prolactin release.
Utility: Antiemetic, esp. w/cancer chemotherapy, and emergency surgery/labor to prevent aspiration of gastric contents.
Special Features: Best if admin. prophylactically.