Name: Amphetamine
Class: CNS-Active Sympathomimetic Agent (Indirect)
Mechanism: Indirect agonist of symp. receptors. Potent CNS and peripheral effects. Displaces catecholamines from storage vesicles. Reverses Uptake I transporter ® NE release. Causes systolic & diastolic BP. HR often reflexively slowed. Contraction of urinary sphincter. Typical symp. effects.
Absorption: Oral ® good bioavail.
Dist.: Crosses BBB.
Metabolism.:
Excretion, t½:
Toxicity/S.E.s:
Utility: Treat narcolepsy, ADHD.
Special Features: Not Metabolism. by COMT. Decreased Metabolism. by MAO.