Name: Rocuronium (Zemuron)
Class: Competitive Neuromuscular Blocking Agent
Mech.: Competitive antagonism of ACh on nicotinic receptors at NMJ ® skeletal muscle paralysis.
Absorption:
Dist.:
Metab.: Hepatic uptake.
Excretion, t½: Biliary excretion. Minimal kidney excretion. Effect begins in 1-2 min. Duration 15-30 min.
Toxicity/S.E.s:
Utility: Relaxes skeletal muscle, esp. abdominal wall. Used in surgery.
Special Features: No histamine release. No ganglionic blockade. Non-cumulative effect. Widely used. Negligible CV effect.