Name: Methyldopa (Aldomet)
Class: Centrally Acting Antiadrenergic Agent
Mechanism: Stim. inhib. a2 receptors in central cardiovasc pathways involving EPI or NE. a2 are G-protein coupled to inhibit adenylyl cyclase ®
¯ cAMP ® ¯ central symp. activity.
Absorption:
Dist.: Act at medullary and spinal sites.
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Prominent sedation, dry mouth, nightmares, depression, movement disorders, endocrine disturbances (lactation), anemia, rare hypersensitivity of skin and liver. Possible toxic psychosis if given w/levodopa.
Utility: Treat hypertension.
Special Features: Activates a2 via Metabolismolite, methylnorepinephrine (false transmitter). Probably the most used hypotensive agent in mgt. of pregnant E.