Name: Cimetidine (Tagamet)
Class: H2-Histamine Antagonist
Mech.: Competitive inhib. of histamine and histamine receptor interaction.
Absorption: Oral
Dist.:
Metab.:
Excretion, t½:
Toxicity/S.E.s: Reversible gynecomastia. Dose-dependent elevation in prolactin. Slows hepatic microsomal metab. of some drugs. Headache.
Utility: Reduces gastric acid secretion by over 90% after a single dose. Used to treat duodenal and gastric ulcers.
Special Features: