Other Migraine Drugs
b Blockers: Propanolol, timolol, nadolol, metoprolol for continuous prophylaxis. S.E.s include fatigue, depression, orthostatic hypotension. C/I in asthmatics & congestive heart failure patients.
Ca2+ Channel Blockers: Verapamil & flunarazine ® moderatey efficacious prophylaxis.
Analgesics: Fiorinal: aspirin + caffeine + butalbital. Midrin: acetaminophen + isometheptene (sympathomimetic) + dichloralphenazone (sedative). NSAIDS, esp. naproxen sodium (but ¯ gastric motility during acute attack may interfere w/absorption). Butorphanol (opioid agonist antagonist) nasal spray. Methadone (IM).
Overuse may cause a headache (“analgesic rebound”).