Name: Ergotamine
Class: Anti-Migraine (Serotonin Agonist)
Mechanism: Partial agony at 5-HT2 vascular receptors & partial agonist at a-adrenergic receptors (can act as a blocker) ® vasoconstriction (cerebral vasc. most sensitive), uterine smooth muscle contraction, n/v, diarrhea.
Absorption: IV, IM, oral, sublingual, rectal, & inhaler.
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Most common = GI (n/v, diarrhea). Most dangerous = vasospasm from overuse/overdose (intense & prolonged, but can be blocked w/a blockers). Drowsiness.
Utility: Treat migraines.
Special Features: Most effective when given during prodrome period. Often combined w/caffeine to facilitate absorption.