Name: Disulfiram (Antabuse)
Class: Aversive Agent
Mechanism: Irreversibly inactivates aldehyde dehydrogenase.
Absorption:
Dist.:
Metabolism.:
Excretion, t½: Effective for 2-3 days.
Toxicity/S.E.s: Dizziness, metallic taste, nausea, headache, skin reactions.
Utility: Used to treat alcoholism. When alcohol is ingested, blood acetaldehyde concentrations rise, producing hangover symptoms of flushing, headache, nausea, vomiting, and hypotension.
Special Features: