Name: Terazosin (Hytrin)
Class: a-Blocking Agent (Prazosin-type)
Mechanism: Blocks a1 receptors in vasculature.
Absorption: Oral. High bioavailability.
Dist.:
Metabolism.:
Excretion, t½: 9-12 hr.
Toxicity/S.E.s: 1st dose syncope (1%).
Utility: Treat periph. vasc. disease (Raynaud’s Disease), hypertension, pheochromocytoma (phenoxybenz. is best), benign prostatic hyperplasia (relieves obstruction symptoms).
Special Features: Prazosin-type a blockers are the only clinically useful anti-hypertensive a-receptor antagonists. Lower BP w/o producing sig. tachycardia. Readily combined w/other drugs.