Name: Acyclovir (Zovirax)
Class: Antiviral
Mech.: Inhib. DNA synthase (most selective for herpes virus). Phosphorylated by viral thymidine kinase. Then inhib. viral DNA polymerase by competing w/deoxyguanosine triphosphate.
Absorption:
Distribution:some CSF
Metab.:
Excretion, t½: Renal secretion, 2.5 hr.
Toxicity/S.E.s: Topical admin may cause loal irritation. IV may cause local phlebitis, rash. Encephalophaty in renal-impaired.
Utility: Topical, oral, IV application to treat herpes infections.
Special Features: