Name: Scopolamine (Transderm-Scop)
Class: Tertiary M2-Muscarinic Antagonist
Mech.: Bind to muscarinic receptors and competitively inhib. ACh interaction.
Absorption: Oral, transdermal, parenteral.
Dist.:
Metab.:
Excretion, t½:
Toxicity/S.E.s: Drowsiness, blurred vision, dry mouth, urinary retention, tachycardia, constipation, cyclopegia. Mostly avoided w/transdermal application.
Utility: Prevent motion sickness (transdermal patch). Give parenterally in advance to counteract nasty anesthesia side effects (cardiac slowing, salivation, bronchial secretions).
Features: In addition to atropine-like anti-musc properties, also produces central depressant and anti-motion sickness effects. Best if admin. prophylactically.