Rifampin (Rifadin) -|- Pharmacology Mnemonics - Flash Cards

Rifampin (Rifadin)

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Name: Rifampin (Rifadin)

Class: Antitubercular

Mech.: Inhib. of bact. DNA-dependent RNA polymerase. Resist develops rapidly.

Absorption: Orally effective

Distribution: Diffuses freely into tissues and fluids

Metab.: Liver

Excretion, t½: 30% excreted in urine (50% active). T1/2= 1.5-5 hrs. ¯ in slow acetylaters.

Toxicity/S.E.s: Low incidence. Jaundice (can be fatal). Use w/caution w/impaired liver fxn. Induces hepatic microsomal enzymes. GI distress, diarrhea, CNS complaints, hypersensitivity. Influenza-like syndrome.

Utility: Rapidly improves TB patients to non-infectious state. Always used w/other agents. Esp. useful in serious cases of TB. Asymptomatic carriers of N. meningitis, eryth-resist. Legionella pneumophila infects. DOC for prophylaxis of H. influenza meningitis.