Ribavirin (Virazole) -|- Pharmacology Mnemonics - Flash Cards

Ribavirin (Virazole)

Post a comment

Name: Ribavirin (Virazole)

Class: Antiviral

Mech.: Purine analog. After phosphorylation, inhibits enzymes involved in guanine nucleotide synth. After further phosph, inhib several viral-specific enzymes involved in DNA synth.

Absorption: Oral bioavail 45%. IV. Aerosol.

Distribution:

Metab.:

Excretion, t½: 40 days

Toxicity/S.E.s: Accumulates in erythrocytes ® hemolytic anemia. Bone marrow suppression. GI, CNS aggravation. Teratogenic and mutagenic in animals. Toxicity avoided w/aerosol admin (for RSV). Antagonizes AZT activity.

Utility: Aerosol form used to treat respiratory syncytial virus. Most important drug for treatment of hemorrhagic fever.

Special Features: