Edrophonium (Tensilon) -|- Pharmacology Mnemonics - Flash Cards

Edrophonium (Tensilon)

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Name: Edrophonium (Tensilon)

Class: Anticholinesterase Agent: Choline Analog

Mech.: Combines w/AChE. Competitively prevents interaction of ACh w/AChE.

Absorption:

Dist.: No CNS. Acts mostly at neuromusc sites. Some autonomic action.

Metab.:

Excretion, : Brief duration of action (several min.) because binding is rapidly reversible.

Toxicity/S.E.s: Toxic doses first stim. then depress autonomic ganglia, neuromusc. jxns, and central sites. IV—­ skeletal muscle strength = myasthenic weakness; ¯ strength = cholinergic crisis. Avoid in cases of asthma, coronary insufficiency, peptic ulcers.

Utility: IV—test for myasthenia gravis. Antag. NM blockade of curare-like agents. Treat paroxysmal supraventricular tachycardia.

Special Features: IV ® Non-selective. Stim. cholinergic receptors throughout CNS and PNS. Inhib. AChE and BuChE.