Clortrimazole (Lotrimin) -|- Pharmacology Mnemonics - Flash Cards

Clortrimazole (Lotrimin)

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Name: Clortrimazole (Lotrimin)

Class: Antifungal (Imidazole) (OTC)

Mech.: Causes leakage of small molecules/ions across plasma membrane. Also blocks purine uptake. Fungistatic at low conc. Fungicidal at high conc.

Absorption: Good oral, but not admin due to GI irritation. Topical.

Distribution: Good CSF

Toxicity/S.E.s: Topical ® occasional burning and irritation.

Utility: Topical against common fungal infections of skin and vagina. Better than nystatin for vaginal candidiasis. Esp. useful in mixed skin infections featuring dermatophytes and Candida. Good topical agent for dermatophytoses. Troches esp. recommended for oropharyngeal candidiasis.

Special Features: Safe during pregnancy. Broad spectrum against fungi. Also active against gram+ bacteria. At high conc, also trichomonocidal.