Name: Aztreonam (Azactam)
Class: b-lactam (Monobactam)
Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.
Absorption:
Distribution:
Metab.:
Excretion, t½:
Toxicity/S.E.s: Gram+ superinfections.
Utility: Infections caused by susceptible orgs. resistant to other drugs.
Special Features: Not fused bicyclic. Potent gram-, but limited spectrum (only aerobics and facultative gram-). Little cross-allergenicity w/pen. or ceph. Less toxic than aminoglycs. Usu used in combinations (except for UTIs).