Nitrofurantoin (Furadantin) -|- Pharmacology Mnemonics - Flash Cards

Nitrofurantoin (Furadantin)

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Name: Nitrofurantoin (Furadantin)

Class: UTI Agent

Mech.: Unclear. Baceria activate nitrofurantoin more rapidly than do mammalian cells. Bacteriostatic in low conc., cidal in high conc.

Absorption: Rapidly and completely absorbed after oral admin.

Distribution: Antibact. conc. not achieved in plasma. Active in urine.

Metab.:

Excretion, t½:

Toxicity/S.E.s: GI effects, pulm. toxicity (acute pneumoinitis, subacute interstitial pulonary fibrosis), hypersensitivity rxns. chronic hepatitis, neuro efffects. Turns urine brown. Not for preg. women or infants (hemolytic anemia). Not to be mixed w/probenecid.

Utility: Uncomplicated lower UTIs caused by E. coli, Enteroccus, prevention of recurrence of UTIs.

Special Features: Effect enhanced by urine pH£5.5.