Cefaclor (Ceclor) -|- Pharmacology Mnemonics - Flash Cards

Cefaclor (Ceclor)

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Name: Cefaclor (Ceclor)

Class: Second Gen. Cephalosporin

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: Oral.

Distribution: Poor CSF.

Metab.:

Excretion, t½:

Toxicity/S.E.s: Hypersensitivity (some cross-sensitivity to pen.), superinfection, renal damage (worse if comb. w/aminoglycs.)

Utility: Resp. and middle ear infections (H. influenzae, M. catarrhalis)

Special Features: More gram- efficacy than first gen. Less gram+ cocci efficacy than first gen. ­ b-lactamase resistance. Problem w/bacterial resistance.