Name: Vancomycin (Vancocin)
Class: Polypeptide
Mech.: Blocks peptidoglycan polymerization ® inhib cell wall synth. Bactericidal.
Absorption: Poorly absorbed from GI tract. Usu given IV
Distribution: Poor CNS
Metab.:
Excretion, t½: Renal excretion
Toxicity/S.E.s: Ototoxicity, nephrotoxicity, thrombophlebitis (IV). In patients w/AIDS, “red man” syndrome (diffuse flushing)
Utility: Last ditch measure against severe MRSA infects. DOC for antibiotic assoc. pseudomembranous colitis (oral).
Special Features: Narrow spectrum (gram+ cocci), spec. MRSA, C. difficile.