Name: Erythromycin
Class: Macrolide
Mech.: Inhib protein synth by binding to 50S rib. subunit. Bacteriostatic
Absorption: Orally effective. Enteric-coated tablets.
Distribution: Good tissue penetration, but poor CSF.
Metab.: Hepatic metab.
Excretion, t½: Secreted in bile as active drug. 1.6 hr.
Toxicity/S.E.s: GI irritation.,rashes, ototoxicity (large parenteral doses), drug interactions due to inhib of hepatic metab.
Utility: Alternate to pen. in mild-moderate infects (esp. Strep, H. influenzae). DOC for Legionnaire’s disease, Diphtheria carrier state, Mycoplasma pneumoniae infects, Whooping cough (Bordatella pertussis)
Special Features: Not recommended for severe staph. infections or for meningitis.