Imipenem -|- Pharmacology Mnemonics - Flash Cards

Imipenem

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Name: Imipenem

Class: b-lactam (Carbapenem)

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: Oral, IV (painful)

Distribution:

Metab.:

Excretion, t½:

Toxicity/S.E.s: painful injection, allergy, nausea/vomiting, superinfection (diarrhea), reversible blood disorders.

Utility: Combined w/equal amts of cilastatin to block tubular metab. and formation of nephrotoxic compounds. Treats serious nosocomial infections, infections of unknown etiology, mixed infections.

Special Features: Broadest spectrum of all b-lactams. Resistant to penicillinases and most b-lactamases. Resistance develops during treatment.