Azidothymidine (Zidovudine, AZT) -|- Pharmacology Mnemonics - Flash Cards

Azidothymidine (Zidovudine, AZT)

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Name: Azidothymidine (Zidovudine, AZT)

Class: Antiviral

Mech: Thymidine analog. After phosph, inhib. viral RNA-dependent DNA polymerase (reverse transcriptase). Causes chain termination after incorporation.

Absorption: Oral bioavail 60-65%.

Distribution: good CSF

Metab.: Metab. to glucuronide. Antag. by ribavirin

Excretion, t½: 1 hr.

Toxicity/S.E.s: Granulocytopenia (45%), anemia (transfusions necessary 30%), headache, nausea, insomnia, myalgia.

Utility: Treatment of HIV. Decreases plasma HIV RNA, increases CD4 cells, decreases # of opportunistic infects, prolongs survival. Reduces risk of transmission by pregnant women to fetuses from 28% to 8%.

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