Name: Dideoxyinosine (Didanosine, Videx, DDI)
Class: Antiviral
Mech.: Inhib reverse transcriptase.
Absorption:
Distribution:
Metab.:
Excretion, t½:
Toxicity/S.E.s: Peripheral neuropathy, rash, stomatitis, esophageal ulceration, pancreatitis, fever.
Utility: Treat HIV. Strains resistant to AZT may be susceptible. After treatment, may become susceptible again to AZT. Alternating treatment superior to either alone.
Special Features: