Echothiophate (Phospholine) -|- Pharmacology Mnemonics - Flash Cards

Echothiophate (Phospholine)

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Name: Echothiophate (Phospholine)

Class: Anticholinesterase Agent: Organophosphate

Mech.: Binds irreversibly to AChE

Absorption: Eye drops.

Dist.:

Metab.:

Excretion, : Long-lasting inhibition—days to weeks.

Toxicity/S.E.s: Toxic doses first stim. then depress autonomic ganglia, neuromusc. jxns, and central sites. Treat w/heroic doses of atropine for muscarinic effects, pralidoxine for neuromusc effects.

Utility: Topical eye applic. to treat glaucoma. For closed-angle glaucoma, stim. constriction of iris sphincter ® iris removed from entrance to trabecular space. For open-angle glaucoma, stim. sphincter and ciliary body contraction ® ­ patency of trabecular network. Topical to treat crossed eyes.

Special Features: Bond btwn drug and AChE must age before becoming irreversible. While bond is aging, drugs such as pralidoxime can reactivate AChE.