Name: Itraconazole (Sporanox)
Class: Antifungal (Triazole)
Mech.: Inhib. cytochrome P450-dependent synth of ergosterol.
Absorption: Oral absorption good. Better in presence of food, high gastric acidity.
Distribution: Neglibible CSF, saliva.
Metab.: Extensively metab. in liver.
Excretion, t½: Very little active drug remains in urine.
Toxicity/S.E.s: Nausea, vomiting, headache, rash, loss of libido, impotence, gynecomastia. Rare hepatotoxicity. Inhib. metab. of long-acting antihistamines (sim. to ketoconazole), erythromycin, triazolam, cisapride.
Utility: DOC for many superficial and systemic infections. Alternate for many superf. and systemic infections. Oral treatment of onychomycoses. Same indications as ketocon., but also active against lymphocutaneous form of sporotrichosis plus Aspergillosis. Usu. preferred to ketoconazole.
Special Features: