Name: Norfloxacin (Noroxin)
Class: Fluorinated quinolone
Mech.: Inhib bact. DNA gyrase (topoisomerase II). Bactericidal.
Absorption: Oral admin.
Distribution: Good tissue penetration.
Metab.:
Excretion, t½:
Toxicity/S.E.s: Usu. not severe. GI, CNS. Not for pregnant or nursing women or prepubertal children.
Utility: UTIs due to Enterobacteriaceae, Enteroccus, Staph, Pseudomonas.
Special Features: Broader spectrum than nonfluorinated quinolones.