Cephalothin (Keflin) -|- Pharmacology Mnemonics - Flash Cards

Cephalothin (Keflin)

Post a comment

Name: Cephalothin (Keflin)

Class: First Gen. Cephalosporin

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: IV. IM rarely used due to pain.

Distribution: Poor CSF.

Metab.:

Excretion, t½:

Toxicity/S.E.s: Hypersensitivity (some cross-sensitivity to pen.), superinfection, renal damage (worse if comb. w/aminoglycs.)

Utility: Usu not DOC. Serious Klebsiella infects., strep/staph infects, some penicillinase-producing bacteria.

Special Features: Narrow spectrum. Greater gram - activity than pen. G. More gram+ activity than gram - activity. Less susceptible to b-lactamase than most penicillins.